Biocooperative Regenerative Materials by Harnessing Blood-Clotting and Peptide Self-Assembly.

ABSTRACT: The immune system has evolved to heal small ruptures and fractures with remarkable efficacy through regulation of the regenerative hematoma (RH); a rich and dynamic environment that coordinates numerous molecular and cellular processes to achieve complete repair. Here, a biocooperative approach that harnesses endogenous molecules and natural healing to engineer personalized regenerative materials is presented. Peptide amphiphiles (PAs) are co-assembled with blood components during coagulation to engineer a living material that exhibits key compositional and structural properties of the RH. By exploiting non-selective and selective PA-blood interactions, the material can be immediately manipulated, mechanically-tuned, and 3D printed. The material preserves normal platelet behavior, generate

SUBMITTER: Padilla-Lopategui S 

PROVIDER: S-EPMC11681309 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature