Nanobodies Outperform Antibodies - Rapid Functionalization with Equal In Vivo Targeting Properties.

ABSTRACT: Highly specific targeting of dendritic cells in vivo is crucial for the development of effective tumor nanovaccines. This group recently presented an antibody-functionalized nanocarrier system able to maintain its targeting properties when transferred from in vitro to in vivo studies. However, producing this system requires long synthesis times and involves high expenses due to the involved site-specific enzymatic multi-step modification procedure of the antibody. Consequently, improving the previously proposed system is necessary in order to accelerate the development. Here, a novel system utilizing nanobodies for the targeting of dendritic cells is presented. A C-terminal cysteine tag facilitates an easy attachment of the nanobody to the nanocarrier via a thiol-maleimide conjugation tech

SUBMITTER: Jung C 

PROVIDER: S-EPMC11681313 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature