Symptoms Prior to Diagnosis of Multiple Sclerosis in Individuals Younger Than 18 Years.

ABSTRACT:

Importance

A growing body of literature suggests the presence of a prodromal period with nonspecific signs and symptoms before onset of multiple sclerosis (MS).

Objective

To systematically assess diseases and symptoms diagnosed in the 5 years before a first MS- or central nervous system (CNS) demyelinating disease-related diagnostic code in pediatric patients compared with controls without MS and controls with another immune-mediated disorder, juvenile idiopathic arthritis (JIA).

Design, setting, and participants

This population-based, matched case-control study included children and adolescents (aged <18 years) in Germany with statutory health insurance from January 2010 to December 2020. The study population consisted of 3 groups: case individuals with MS, control i

SUBMITTER: Akmatov MK 

PROVIDER: S-EPMC11681376 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature