Subcellular spatial regulation of immunity-induced phosphorylation of RIN4 links PAMP-triggered immunity to Exo70B1.

ABSTRACT: RIN4 is a crucial regulator of plant immunity, playing a role in both PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI). While the impact of post-translational modifications (PTMs) on RIN4 has been extensively studied, their specific effects on plant immune response regulation and the underlying mechanisms have remained unclear. In this study, we investigated the phosphorylation of RIN4 at threonine-166 (RIN4^T166) in Arabidopsis transgenic lines expressing various RIN4 variants. Our pathological and molecular genetic analyses reveal that RIN4^T166 phosphorylation disrupts its localization to the plasma membrane (PM) and represses plant defense activation. We found that RIN4's PM tethering relies on Exo70B1-mediated exocytosis and the integrity

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11681384 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature