Combined Effect of Air Pollution and Genetic Risk on Incident Cardiovascular Diseases.

ABSTRACT:

Background

Whether genetic susceptibility to cardiovascular diseases (CVDs) enhances the vulnerability to adverse cardiovascular outcomes by air pollution is unknown. We assessed the combined effect of air pollution and genetic predispositions on CVD risk.

Methods and results

From the UK Biobank cohort, we selected genetically unrelated White British participants without CVD. Levels of ambient particulate matter with a diameter of <2.5 μm (PM_2.5) and <10 μm were estimated using land use regression models. An individual's genetic predisposition to CVDs was determined by polygenic risk scores for coronary artery disease, myocardial infarction, stroke, ischemic stroke, heart failure, and atrial fibrillation. We stratified mortality and CVD risk by PM_2.5 ex

SUBMITTER: Rhee TM 

PROVIDER: S-EPMC11681391 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature