Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy.

ABSTRACT:

Background

White matter hyperintensities (WMHs) are frequently observed on magnetic resonance imaging (MRI) in patients with cerebral amyloid angiopathy (CAA). The neuropathological substrates that underlie WMHs in CAA are unclear, and it remains largely unexplored whether the different WMH distribution patterns associated with CAA (posterior confluent and subcortical multispot) reflect alternative pathophysiological mechanisms.

Methods and results

We performed a combined in vivo MRI-ex vivo MRI-neuropathological study in patients with definite CAA. Formalin-fixed hemispheres from 19 patients with CAA, most of whom also had in vivo MRI available, underwent 3T MRI, followed by standard neuropathological examination of the hemispheres and targeted neuropathological assessment

SUBMITTER: Makkinejad N 

PROVIDER: S-EPMC11681407 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature