IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid.

ABSTRACT:

Introduction

Bullous pemphigoid (BP) and prurigo nodularis (PN) are chronic pruritic skin diseases that severely impact patients' quality of life. Despite the widespread attention these two diseases have garnered within the dermatological field, the specific pathogenesis, particularly the molecular mechanisms underlying the pruritus, remains largely unclear. Limited clinical sequencing studies focusing on BP and PN have hindered the identification of pathological mechanisms and the exploration of effective treatment strategies.

Methods

To address this gap, we collected a total of 23 peripheral blood mononuclear cell samples from BP and PN patients, as well as healthy controls, and performed RNA sequencing analysis. By integrating bioinformatics and machine learning technique

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11681427 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature