Serum Soluble Corin and Long-Term Clinical Outcomes After Acute Ischemic Stroke.

ABSTRACT:

Background

Corin plays important roles in the regulation of blood volume and pressure and cardiac function by activating natriuretic peptide pathway, exerting multiple cardioprotective effects. But the impacts of soluble corin on clinical outcomes after ischemic stroke are unclear. We aimed to investigate the associations between serum soluble corin and long-term clinical outcomes after acute ischemic stroke.

Methods and results

We measured the concentrations of serum soluble corin in 3162 participants (2010 men and 1152 women) from the China Antihypertensive Trial in Acute Ischemic Stroke. The clinical outcomes were recurrent stroke, cardiovascular events, all-cause mortality, and unfavorable functional outcome within 24 months after stroke. Risk reclassification for study

SUBMITTER: Wang A 

PROVIDER: S-EPMC11681441 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature