Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.

ABSTRACT:

Background

The essential hypertension phenotype results from an interplay between genetic and environmental factors. The influence of lifestyle exposures such as excess adiposity, alcohol consumption, tobacco use, diet, and activity patterns on blood pressure (BP) is well established. Additionally, polygenic risk scores for BP traits are associated with clinically significant phenotypic variation. However, interactions between genetic and environmental risk factors in hypertension morbidity and mortality are poorly characterized.

Methods and results

We used genotype and phenotype data from up to 49 234 participants from the HUNT (Trøndelag Health Study) to model gene-environment interactions between genome-wide polygenic risk scores for systolic BP and diastolic BP and 125 e

SUBMITTER: Ovretveit K 

PROVIDER: S-EPMC11681455 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature