Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.

ABSTRACT:

Background

As a risk factor of cardiovascular diseases, homocysteine can be effectively lowered by folate. However, the associations of folate and homocysteine levels with the prognosis of ischemic stroke remained unclear.

Methods and results

A total of 3530 patients with ischemic stroke were included. Serum folate and homocysteine levels were measured at admission. The primary outcome was composite of death and major disability (modified Rankin Scale score≥3) at 3 months after stroke onset. Univariate and multivariate logistic regression models were used. The mediation effect of homocysteine was examined. During follow-up, 1056 participants developed the primary outcome. In the univariate model, participants in the highest quartile of folate had a 29% (95% CI, 0.58-0.87) de

SUBMITTER: Shi M 

PROVIDER: S-EPMC11681484 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature