Genetic Determinants of Left Atrial Function Are Associated With Stroke.

ABSTRACT:

Background

While atrial fibrillation (AF) is a key risk factor for stroke, recent studies have suggested that atrial cardiomyopathy may also increase stroke risk in the absence of AF. This study aimed to evaluate genetic determinants for left atrial (LA) function and volumes and risk of stroke.

Methods and results

Polygenic scores (PGSs) for LA measures were constructed and used in 380 017 individuals in the UK Biobank, without history of ischemic stroke, systemic arterial embolism, or AF at enrollment. Risk of ischemic stroke was estimated using time-to-event models, considering all-cause death and incident AF as competing events. Systemic arterial embolism was investigated as a secondary end point. The PGS for LA passive emptying fraction was associated with risk of ischem

SUBMITTER: Vad OB 

PROVIDER: S-EPMC11681563 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature