Cytokine Adsorption During Ex Vivo Blood Perfusion Improves Contractility of Donation After Circulatory Death Hearts.

ABSTRACT:

Background

Donation after circulatory death (DCD) hearts have to withstand ischemia/reperfusion injury that is partially driven by proinflammatory cytokines and decreases ventricular contractility. We hypothesize that cytokine adsorption during normothermic ex vivo blood perfusion of DCD hearts reduces the cytokine levels and improves ventricular contractility.

Methods and results

Porcine DCD hearts were maintained 4 hours by ex vivo blood perfusion with (DCD-BP^CytoS, all groups: N=8) or without (DCD-BP) CytoSorb, followed by 2 hours reperfusion with fresh blood, including left ventricular functional analysis using a balloon catheter. In a control and a DCD group, hearts were evaluated after procurement. We determined lactate and cytokines after ex vivo blood perf

SUBMITTER: Saemann L 

PROVIDER: S-EPMC11681589 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature