Lipoprotein(a) Is Elevated and Inversely Related to Coronary Endothelial Function in People With HIV.

ABSTRACT:

Background

HIV-associated cardiovascular disease (CVD) is increasing in prevalence. The mechanisms underlying the heightened cardiovascular risk faced by people with HIV (PWH), however, remain poorly defined. Recent studies indicate an important role of lipoprotein(a) (Lp[a]) in predicting CVD risk in the general population, but little is known regarding its role in HIV-associated CVD. Thus, we sought to evaluate whether Lp(a) is elevated in PWH and if it is associated with impaired coronary endothelial function (CEF), a known mediator of CVD in PWH.

Methods and results

In this cross-sectional study, cardiac magnetic resonance imaging with isometric handgrip exercise, an endothelial dependent stressor, was performed to assess CEF in 65 PWH and 52 controls without HIV. Percen

SUBMITTER: Kikuchi DS 

PROVIDER: S-EPMC11681595 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature