Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases.

ABSTRACT:

Background

The underlying biological mechanisms linking blood pressure (BP) and cardiovascular diseases (CVD) are only partly understood. We aimed to identify metabolic signatures associated with systolic and diastolic BP and investigate their subsequent association with risk of CVD.

Methods and results

The study included 201 742 UK Biobank participants with measurements on 249 metabolic biomarkers. A multistep adaptive elastic net penalized regression with 10-fold cross-validation was employed to identify metabolic signatures for systolic BP and diastolic BP. External validation was conducted on 848 participants from the EHS (Epirus Health Study). We further assessed the associations between BP metabolic signatures and incident composite CVD (N=6742), myocardial infarction

SUBMITTER: Manou M 

PROVIDER: S-EPMC11681602 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature