Clonal Hematopoiesis in Chronic Thromboembolic Pulmonary Hypertension.

ABSTRACT:

Background

The cause of chronic thromboembolic pulmonary hypertension (CTEPH) remains largely unknown. Recently, clonal hematopoiesis (CH) has been reported to be associated with cardiovascular and thromboembolic diseases. Here, we investigated the prevalence and clinical impact of CH in patients with CTEPH.

Methods and results

Whole-exome sequencing and deep-panel sequencing were performed in 214 patients with CTEPH. Clinical data before and after treatment were compared between patients with and without CH. RNA sequencing and serum analysis were performed to explore the pathogenesis that CH contributes to CTEPH. Among the enrolled patients, 20.1%, notably 44.4% who were 80 to 89 years old, had variants in CH-associated genes. In regard to clinical impact, B-type natriureti

SUBMITTER: Momoi M 

PROVIDER: S-EPMC11681603 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature