Acidity induces durable enhancement of T_reg cell suppressive functions for tumor immune evasion.

ABSTRACT: The microenvironment within solid tumors often becomes acidic due to various factors associated with abnormal metabolism and cellular activities, including increased lactate production as a result of dysregulated tumor glycolysis. Recently, we have identified multiple tumor microenvironment (TME) factors that potentiate regulatory T (T_reg) cell function in evading anti-tumor immunosurveillance. Despite the strong correlation between lactate and acidity, the potential roles of acidity in intratumoral T_reg cell adaptation and underlying molecular mechanisms have gone largely unstudied. In this study, we demonstrate that acidity significantly enhances immunosuppressive functions of nT_reg cells, but not iT_reg cells, without altering the expression of

SUBMITTER: Mani NL 

PROVIDER: S-EPMC11681611 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature