HIF-1α mediates hypertension and vascular remodeling in sleep apnea via hippo-YAP pathway activation.

ABSTRACT:

Background

Sleep apnea syndrome (SAS) is associated with hypertension and vascular remodeling. Hypoxia-inducible factor-1α (HIF-1α) and the Hippo-YAP pathway are implicated in these processes, but their specific roles remain unclear. This study investigated the HIF-1α/Hippo-YAP pathway in SAS-related hypertension.

Methods

We established a rat model of SAS-induced hypertension via chronic intermittent hypoxia (CIH). Rats were treated with siRNA targeting HIF-1α. Blood pressure, inflammation, oxidative stress, vascular remodeling, and VSMC function were assessed. In vitro experiments with A7r5 cells and human aortic smooth muscle cells (HAoSMCs) explored the effects of HIF-1α silencing and YAP1 overexpression.

Results

Compared with the control group, the CIH group prese

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11681631 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature