Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer.

ABSTRACT: Gas therapy represents a promising strategy for cancer treatment, with nitric oxide (NO) therapy showing particular potential in tumor therapy. However, ensuring sufficient production of NO remains a significant challenge. Leveraging ultrasound-responsive nanoparticles to promote the release of NO is an emerging way to solve this challenge. In this study, we successfully constructed ultrasound-responsive nanoparticles, which consisted of poly (D, L-lactide-co-glycolic acid) (PLGA) nanoparticles, natural L-arginine (LA), and superparamagnetic iron oxide nanoparticles (SPIO, Fe₃O₄ NPs), denote as Fe₃O₄-LA-PLGA NPs. The Fe₃O₄-LA-PLGA NPs exhibited effective therapeutic effects both in vitro and in vivo, particularly in NO-assis

SUBMITTER: Yang H 

PROVIDER: S-EPMC11681665 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature