Gene expression profiling for the diagnosis of male breast cancer.

ABSTRACT:

Background

Male breast cancer (MBC) is a rare malignancy, but its global incidence has shown a notable increase in recent decades. Factors such as limited health literacy, inadequate health education, and reluctance to seek medical attention contribute to the late-stage diagnosis of most MBC patients. Consequently, there is an urgent need for a highly specific and sensitive diagnostic approach to MBC.

Methods

This retrospective study enrolled 20 patients with 30 surgical or biopsy MBC specimens from August 2020 to August 2023. The 90-gene expression assay was performed to determine the tissue of origin. Predicted tumor types were then compared to the reference diagnosis for accuracy calculation. The differentially expressed genes were identified between male and female breas

SUBMITTER: Liu J 

PROVIDER: S-EPMC11681697 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature