Organoids as a model system for researching human neuroendocrine tumor of the breast.

ABSTRACT:

Background

Neuroendocrine tumors primarily consist of endocrine cells commonly located in neural tissue and the endocrine system. Primary neuroendocrine neoplasms of the breast are highly heterogeneous tumors characterized by a diverse cell population. Their rarity in the breast poses considerable challenges in studying their pathogenesis and developing effective treatments.

Methods

The surgical specimen was obtained from a Chinese female patient diagnosed with neuroendocrine tumor of the breast (NETB). We performed tissue histological staining and established NETB patient-derived organoids, which were subsequently used for histological staining, drug screen, and Single-cell RNA sequencing.

Results

We successfully established NETB patient-derived organoids from a Chin

SUBMITTER: Zhao D 

PROVIDER: S-EPMC11681707 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature