In vivo imaging of adipose-derived stem cell sheets on biodegradable nonwoven fabric using X-ray CT.

ABSTRACT:

Background

A biodegradable nonwoven fabric that can be used to extract adipose-derived stem cells (ADSCs) from adipose tissue slices was developed, which were cultured rapidly without enzymatic treatment. The extracted and cultured ADSCs remain on the nonwoven fabric and form a thick cell sheet. The aim was to use the thick cell sheet as a treatment by transplanting it into the living body. In addition, the expectation was that it will be possible to observe the cell sheet in the living body using X-ray computed tomography (CT) because the nonwoven fabric used to produce the cell sheet contains 50% (by weight) hydroxyapatite.

Results

Thick cell sheets of ADSCs supported by two layers of nonwoven fabric were cut to size and transplanted into the cheeks of rats. No health dama

SUBMITTER: Sunami H 

PROVIDER: S-EPMC11681712 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature