LPL-RH suppresses bone loss in ovariectomised rat models.

ABSTRACT:

Background

Evidence has revealed that oestrogen deprivation-induced osteolysis is microbiota-dependent and can be treated by probiotics. However, the underlying mechanism require further investigation. This study aims to provide additional evidence supporting the use of probiotics as an adjuvant treatment and to explore the pathophysiology of oestrogen-deprived osteolysis.

Methods

Forty-five SD rats were randomly divided into five groups (n = 9). Rats from four groups were ovariectomised and treated with NS, calcium, probiotics, or calcium + probiotics, while one group underwent a sham operation and was treated with NS. The osteometabolic effects were evaluated, and the mechanistic role of the probiotic supplement was explored.

Results

Intragastric administration of B

SUBMITTER: Chen WJ 

PROVIDER: S-EPMC11681754 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature