Innate immune response after BNT162b2 COVID-19 vaccination associates with reactogenicity.

ABSTRACT:

Background

The innate immune response is important for the development of the specific adaptive immunity, however it may also be associated with reactogenicity after vaccination. We explore the association between innate responsiveness, reactogenicity, and antibody response after first COVID-19 vaccination.

Methods

We included 146 healthy Dutch individuals aged 12-59 who received their first BNT162b2 (Comirnaty, Pfizer) COVID-19 vaccination. Data on reactogenicity were collected for each individual through daily questionnaires from day 0-5 after vaccination. From 60 participants, serum (adults) and plasma (adolescents) samples were collected before and/or 2 ± 1 days after vaccination to measure cytokines/chemokines as markers for innate responsiveness. Each individual was ca

SUBMITTER: van Ewijk CE 

PROVIDER: S-EPMC11681879 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature