Uncovering novel therapeutic clues for hypercoagulable active ulcerative colitis: novel findings from old data.

ABSTRACT:

Background

Hypercoagulability has been shown to act as an important component of ulcerative colitis (UC) pathogenesis and disease activity, and is strongly correlated with the occurrence of venous thromboembolism (VTE). This study aimed at providing novel therapeutic clues for hypercoagulable active UC.

Methods

The coagulation score model was developed using VTE cohorts, and the predictive performance of this model was evaluated by coagulation subtypes of UC patients, which were clustered by the unsupervised method. Subsequently, the response of UC of distinct coagulation types, as identified by the coagulation scoring model, to different biological agents was evaluated. Immunoinflammatory cells and molecules that were associated with hypercoagulable active UC were explored

SUBMITTER: Yu Z 

PROVIDER: S-EPMC11681937 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature