Accelerated growth and local progression of radiorecurrent prostate cancer in an orthotopic bioluminescent mouse model.

ABSTRACT: Globally, prostate cancer is the second most common malignancy in males, with over 400 thousand men dying from the disease each year. A common treatment modality for localized prostate cancer is radiotherapy. However, up to half of high-risk patients can relapse with radiorecurrent prostate cancer, the aggressive clinical progression of which remains severely understudied. To address this, we have established an orthotopic mouse model for study that recapitulates the aggressive clinical progression of radiorecurrent prostate cancer. Radiorecurrent DU145 cells which survived conventional fraction (CF) irradiation were orthotopically injected into the prostates of athymic nude mice and monitored with bioluminescent imaging. CF tumours exhibited higher take rates and grew more rapidly than tr

SUBMITTER: Frame G 

PROVIDER: S-EPMC11682066 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature