IPSC-derived human sensory neurons reveal a subset of TRPV1 antagonists as anti-pruritic compounds.

ABSTRACT: Signaling interplay between the histamine 1 receptor (H1R) and transient receptor potential cation channel subfamily V member 1 (TRPV1) in mediating histaminergic itch has been well-established in mammalian models, but whether this is conserved in humans remains to be confirmed due to the difficulties in obtaining human sensory neurons (SNs) for experimentation. Additionally, previously reported species-specific differences in TRPV1 function indicate that use of human SNs is vital for drug candidate screening to have a higher chance of identifying clinically effective TRPV1 antagonists. In this study, we built a histamine-dependent itch model using peripheral SNs derived from human induced pluripotent stem cells (hiPSC-SNs), which provides an accessible source of human SNs for pre-clinical

SUBMITTER: Tay SH 

PROVIDER: S-EPMC11682095 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature