Altered neurovascular coupling and structure-function coupling in Moyamoya disease affect postoperative collateral formation.

ABSTRACT: Chronic ischemia in moyamoya disease (MMD) impaired white matter microstructure and neural functional network. However, the coupling between cerebral blood flow (CBF) and functional connectivity and the association between structural and functional network are largely unknown. 38 MMD patients and 20 sex/age-matched healthy controls (HC) were included for T1-weighted imaging, arterial spin labeling imaging, resting-state functional MRI and diffusion tensor imaging. All patients had preoperative and postoperative digital subtraction angiography. Upon constructing the structural connectivity (SC) and functional connectivity (FC) networks, the SC-FC coupling was calculated. After obtaining the graph theoretical parameters, neurovascular coupling represented the spatial correlation between node

SUBMITTER: Jin L 

PROVIDER: S-EPMC11682109 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature