Mendelian randomization analysis reveals causal effects of migraine and its subtypes on early-onset ischemic stroke risk.

ABSTRACT: Previous observational studies have suggested at a potential link between migraine, particularly migraine with aura, and the susceptibility to early-onset ischemic stroke. We aimed to investigate the causal effects of genetically determined migraine and its subtypes on the risk of early-onset ischemic stroke using the two-sample Mendelian randomization method. Genetic instrumental variables associated with migraine and its subtypes were acquired from two sources with the largest sample sizes available. Summary data for early-onset ischemic stroke was acquired from a study encompassing individuals aged 18-59 years, comprising 16,730 cases and 599,237 non-stroke controls. The random-effects inverse variance weighted method was used as the primary analysis approach. Additionally, linkage dise

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11682154 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature