Prognostic value of pseudotime from texture parameters of FDG PET/CT in locally advanced rectal cancer with neoadjuvant concurrent chemoradiotherapy.

ABSTRACT: Texture analysis generates image parameters from F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). Although some parameters correlate with tumor biology and clinical attributes, their types and implications can be complex. To overcome this limitation, pseudotime analysis was applied to texture parameters to estimate changes in individual sample characteristics, and the prognostic significance of the estimated pseudotime of primary tumors was evaluated. Our subjects were 224 rectal cancer patients who underwent pretherapeutic FDG PET/CT and neoadjuvant concurrent chemoradiation therapy (CCRT). Texture parameters of the primary tumor were extracted from FDG PET/CT images acquired before neoadjuvant CCRT. The pseudotime of the primary tumor was successfull

SUBMITTER: Lee H 

PROVIDER: S-EPMC11682166 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature