The platelet and plasma proteome and targeted lipidome in postpartum dairy cows with elevated systemic inflammation.

ABSTRACT: Unregulated, systemic inflammation negatively impacts health and production in dairy cows. Soluble mediators and platelets have been studied for their expansive role in mediating inflammation. Our objectives were to compare the plasma oxylipin and endocannabinoid profiles, and the platelet and plasma proteomic profiles of healthy cows to cows experiencing elevated systemic inflammation as indicated by plasma haptoglobin (Hp) concentrations. Postpartum cows at 3 DIM with plasma Hp concentrations [Formula: see text] 0.50 g/L and no clinical disease were enrolled into the high-inflammation group (n = 8). Cows with plasma Hp concentrations [Formula: see text] 0.1 g/L and no clinical disease were enrolled into the low-inflammation group (n = 8). Targeted lipidomic analysis revealed differences

SUBMITTER: Grantz JM 

PROVIDER: S-EPMC11682181 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature