ICEmST contributes to colonization of Salmonella in the intestine of piglets.

ABSTRACT: Salmonella enterica serovar 4,[5],12:i:- sequence type 34 (ST34) has recently become a global concern for public and animal health. The acquisition of mobile genetic element ICEmST, which contains two copper tolerance gene clusters, cus and pco, influences the epidemic success of this clone. Copper is used as a feed additive in swine at levels that potentially lead to selection pressure for Enterobacteriaceae; however, it remains unclear whether the copper tolerance system of ICEmST functions in vivo. We performed competition assays with Salmonella 4,[5],12:i:- ST34 wildtype (WT) and deletion mutants of ICEmST (ΔICEmST, Δcus, and Δpco) in groups of mice fed 0, 150, and 500 ppm CuSO₄. In the competition of WT against ΔICEmST and Δcus, the competitive index of the 500 ppm-fed grou

SUBMITTER: Arai N 

PROVIDER: S-EPMC11682193 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature