Bioinformatics identifies key genes and potential therapeutic targets in the pathological mechanism of oxidative stress in Randall's plaque.

ABSTRACT: Randall's plaque (RP) is recognized as a precursor lesion for kidney stones, with its formation and progression potentially linked to oxidative stress. Previous studies have provided limited insights into the underlying mechanisms of RP, failing to fully elucidate its molecular pathways. To investigate the relationship between oxidative stress and RP, we employed bioinformatics approaches to identify key genes, predict associated pathways and drug molecules, analyze variations in immune cell populations, and construct diagnostic models. We initially identified three differentially expressed genes related to oxidative stress: BFSP1, LONF1, and TAF1D. These genes and their co-expressed counterparts are enriched in pathways related to oxidative phosphorylation, cellular adhesion processes, st

SUBMITTER: Li F 

PROVIDER: S-EPMC11682209 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature