Cholesterol mediates the potential adverse influence of graphene quantum dots on placental lipid membrane model.

ABSTRACT: Nanomaterial-biomembrane interactions constitute a critical biological process in assessing the toxicity of such materials in theoretical studies. However, many investigations simplify these interactions by using membrane models containing only one or a few lipid types, deviating significantly from the complexity of real membrane compositions. In particular, cholesterol, a ubiquitous lipid essential for regulating membrane fluidity and closely linked to various diseases, is often overlooked. Consequently, the role of cholesterol in nanomaterial-biomembrane interactions remains poorly understood. In this study, we employ molecular dynamics (MD) simulations to explore the effect of graphene quantum dots (GQDs) on a realistic placental lipid membrane model, aiming to elucidate the role of cho

SUBMITTER: Chen J 

PROVIDER: S-EPMC11682271 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature