High density laminar recordings reveal cell type and layer specific responses to infrared neural stimulation in the rat neocortex.

ABSTRACT: Infrared neural stimulation has consistently shown that temperature is a critical neuronal state variable. However, a comprehensive understanding of the biophysical background is essential. In this study, using high-density laminar electrode recordings, we investigated the impact of pulsed and continuous-wave infrared illumination on cortical neurons in anesthetized rats ([Formula: see text]). By analyzing the infrared (IR) stimulation-related responses of more than 7500 single units, we found that elevating tissue temperature with IR stimulation resulted in a significant increase in the number of cells affected, including a substantial rise in the number of inhibited cells. Pulsed stimulation affected an average of [Formula: see text] of units, resulting primarily in increased activity. I

SUBMITTER: Balogh-Lantos Z 

PROVIDER: S-EPMC11682324 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature