Self-propelling, protein-bound magnetic nanobots for efficient in vitro drug delivery in triple negative breast cancer cells.

ABSTRACT: The emergence of self-propelling magnetic nanobots represents a significant advancement in the field of drug delivery. These magneto-nanobots offer precise control over drug targeting and possess the capability to navigate deep into tumor tissues, thereby addressing multiple challenges associated with conventional cancer therapies. Here, Fe-GSH-Protein-Dox, a novel self-propelling magnetic nanobot conjugated with a biocompatible protein surface and loaded with doxorubicin for the treatment of triple-negative breast cancer (TNBC), is reported. The self-propulsion of magnetic nanobots occurs due to a catalytic interaction between Fe₃O₄ nanoparticles and hydrogen peroxide. This interaction results in generation of O₂ bubbles and high-speed propulsion in blood

SUBMITTER: Naikwadi N 

PROVIDER: S-EPMC11682353 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature