Prognostic value and immune infiltration of a tumor microenvironment-related PTPN6 in metastatic melanoma.

ABSTRACT:

Background

Cutaneous melanoma is one of the most invasive and lethal skin malignant tumors. Compared to primary melanoma, metastatic melanoma (MM) presents poorer treatment outcomes and a higher mortality rate. The tumor microenvironment (TME) plays a critical role in MM progression and immunotherapy resistance. This study focuses on the role of the TME-related gene PTPN6 in the prognosis and immunotherapy response of MM.

Methods

This study analyzed the RNA-seq and clinical data of MM patients from public databases, employing the ESTIMATE algorithm and bioinformatics tools to identify differentially expressed genes in the TME. PTPN6 was identified as a prognostic biomarker. Its expression and function were validated using in vitro and in vivo experiments. The role of PTPN6 i

SUBMITTER: Sun R 

PROVIDER: S-EPMC11682626 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature