A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants.

ABSTRACT: Previous computer models have successfully predicted cardiac growth and remodeling in adults with pathologies. However, applying these models to infants is complicated by the fact that they also undergo normal, somatic cardiac growth and remodeling. Therefore, we designed a computational model to predict ventricular dimensions and hemodynamics in healthy, growing infants by modifying an adult canine left ventricular growth model. The heart chambers were modeled as time-varying elastances coupled to a circuit model of the circulation. Circulation parameters were allometrically scaled and adjusted for maturation to simulate birth through 3 yrs of age. Ventricular growth was driven by perturbations in myocyte strain. The model successfully matched clinical measurements of pressures, ventricul

SUBMITTER: Hiebing AA 

PROVIDER: S-EPMC11682707 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature