Accurate Collisional Cross Section Measurement by Multipass Cyclic Ion Mobility Spectrometry.

ABSTRACT: Ion mobility-mass spectrometry (IM-MS) is a powerful analytical tool for structural characterization. IM measurement provides collision cross section (CCS) values that facilitate analyte identification. While CCS values can be directly calculated from mobility measurements obtained using drift tube ion mobility spectrometry (DT-IMS), this method has limited mobility resolution due to the practical constraints on the length of the ion drift path. Consequently, DT-IMS cannot differentiate analytes with similar mobilities or resolve fine mobility features of individual ions. Cyclic IMS (cIMS) instruments leverage a cyclic path enabled by traveling wave ion mobility (TWIM) technology and offer increased mobility solution to address this challenge. While TWIM devices must first be calibrated to

SUBMITTER: Xia C 

PROVIDER: S-EPMC11682735 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature