The characteristic expression of circulating <i>MicroRNAs</i> in osteoporosis: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the characteristics of the circulating microRNA expression profiles in patients with osteoporosis.

Methods

A systematic literature search was performed using the Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and WANFANG databases from inception until 1 March 2024. The search strategy employed keywords, encompassing "osteoporosis", "bone loss", or "osteopenia" and "miRNA" or "microRNA". The Newcastle-Ottawa Scale (NOS) quality assessment scale was used to evaluate the methodological quality. Heterogeneity tests and statistical analyses of all data were performed by Stata 16.0. The differences in microRNA levels between groups were illustrated by the weighted mean difference (WMD) and 95% confidence

SUBMITTER: Gao J 

PROVIDER: S-EPMC11682891 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature