Difficult-to-treat psoriatic arthritis: refining the definition using a statistical model in a real-life cohort.

ABSTRACT:

Objectives

The study aims to evaluate the applicability of the D2T psoriatic arthritis (PsA) definition, adapted from rheumatoid arthritis, within a single-center observational cohort of PsA patients treated with b/tsDMARDs. In addition, we aimed to establish a numerical index defining D2T-PsA based on the ratio of observed to expected failed b/tsDMARDs and to develop a predictive model identifying features associated with the D2T condition.

Methods

The study included 267 consecutive adult PsA patients receiving b/tsDMARDs, collecting demographic, clinical, and clinimetric data. The prevalence of D2T PsA patients was assessed using a proposed definition. We then developed a predictive model to assess treatment difficulty, utilizing PsA-normalized failed b/tsDMARDs. A general

SUBMITTER: Favalli EG 

PROVIDER: S-EPMC11682903 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature