Association between physical activity and sedentary behavior and gestational diabetes mellitus: a Mendelian randomization analysis.

ABSTRACT:

Introduction

The evidence of association between physical activity (PA), sedentary behavior (SB) and gestational diabetes mellitus (GDM) remains controversial in observational studies, this study aimed to generate new hypotheses between PA, SB and GDM.

Methods

Our study performed Mendelian randomization (MR) analysis to explore the effects of three types of PA (moderate physical activity (MPA), moderate to vigorous physical activity (MVPA), accelerometer-based physical activity (ABPA)), three types of SB (television watching (TV), leisure computer use (PC), driving (DR)) on GDM and the mediating effect of body mass index (BMI). The inverse variance weighted method was used for the major analysis.

Results

In univariate MR analysis, we found that genetically predicted T

SUBMITTER: Gao J 

PROVIDER: S-EPMC11682963 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature