The changes of intestinal flora and metabolites in atopic dermatitis mice.

ABSTRACT:

Introduction

Atopic dermatitis (AD) is an allergic disease caused by various factors that can affect an individual's appearance and cause psychological stress. Therefore, it is necessary to investigate the underlying mechanisms and develop effective treatment strategies. The gut microbiota and bacterial metabolism play crucial roles in human diseases. However, their specific role in AD remains unclear.

Methods

In this study, we established a mouse model of AD and found that 2,4-dinitrofluorobenzene disrupted the skin barrier in mice. The species composition of intestinal bacteria was then analyzed by fecal 16s rRNA sequencing. The metabolic level of mice was analyzed by untargeted and targeted metabolomics in stool.

Results

The levels of filaggrin and aquaporin 3 prot

SUBMITTER: Wang F 

PROVIDER: S-EPMC11683101 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature