MiR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells.

ABSTRACT:

Introduction

Hypoxia responses are critical for myriad physiological and pathological processes, such as development, tissue repair, would healing, and tumorigenesis. microRNAs (miRNAs) are a class of small non-coding RNAs that exert their functions by inhibiting the expression of their target genes, and miR-210 is the miRNA universally and most conspicuously upregulated by hypoxia in mammalian systems. For its relationship to hypoxia, miR-210 has been studied extensively, yet no consensus exists on the roles and mechanisms of miR-210 in human physiological processes or diseases, and we know little about genuine miR-210 target genes in humans.

Methods

To better investigate the functions and mechanisms of human miR-210, therefore, we derived the human miR-210 gene knoc

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11683127 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature