A sex-specific effect of M₄ muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine.

ABSTRACT:

Objective

Acetylcholine modulates the activity of the direct and indirect pathways within the striatum through interaction with muscarinic M₄ and M₁ receptors. M₄ receptors are uniquely positioned to regulate plasticity within the direct pathway and play a substantial role in reward and addiction-related behaviors. However, the role of M₄ receptors on cholinergic neurons has been less explored. This study aims to fill this gap by addressing the role of M₄ receptors on cholinergic neurons in these behaviors.

Methods

To investigate the significance of M₄-dependent inhibitory signaling in cholinergic neurons we created mutant mice that lack M₄ receptors on cholinergic neurons. Cholinergic neuron-specif

SUBMITTER: Berezovskaia A 

PROVIDER: S-EPMC11683150 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature