Advanced MRI Measures of Myelin and Axon Volume Identify Repair in Multiple Sclerosis.

ABSTRACT:

Objective

Pathological studies suggest that multiple sclerosis (MS) lesions endure multiple waves of damage and repair; however, the dynamics and characteristics of these processes are poorly understood in patients living with MS.

Methods

We studied 128 MS patients (75 relapsing-remitting, 53 progressive) and 72 healthy controls who underwent advanced magnetic resonance imaging and clinical examination at baseline and 2 years later. Magnetization transfer saturation and multi-shell diffusion imaging were used to quantify longitudinal changes in myelin and axon volumes within MS lesions. Lesions were grouped into 4 classes (repair, damage, mixed repair damage, and stable). The frequency of each class was correlated to clinical measures, demographic characteristics, and levels

SUBMITTER: Sanabria-Diaz G 

PROVIDER: S-EPMC11683175 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature