Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated With Incident Heart Failure Risk.

ABSTRACT:

Background

Higher soluble urokinase plasminogen activator receptor (suPAR) levels are associated with adverse outcomes in chronic heart failure (HF).

Objectives

The authors assessed the association between proteomics-based suPAR levels and incident HF risk in the general population.

Methods

In 40,418 UK Biobank participants without HF or coronary artery disease at enrollment, the association between Olink-based suPAR levels measured as relative protein expression levels and incident all-cause, ischemic, and nonischemic HF was analyzed by competing-risk regression, while accounting for all-cause death as a competing risk. The additional variability in incident HF risk attributable to suPAR levels beyond demographics, traditional risk factors, N-terminal pro B-type natr

SUBMITTER: Yadalam AK 

PROVIDER: S-EPMC11683231 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature