Evaluation of the interface of metallic-coated biodegradable polymeric stents with prokaryotic and eukaryotic cells.

ABSTRACT: Polymeric coronary stents, like the ABSORB™, are commonly used to treat atherosclerosis due to their bioresorbable and cell-compatible polymer structure. However, they face challenges such as high strut thickness, high elastic recoil, and lack of radiopacity. This study aims to address these limitations by modifying degradable stents produced by additive manufacturing with poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) with degradable metallic coatings, specifically zinc (Zn) and magnesium (Mg), deposited via radiofrequency (rf) magnetron sputtering. The characterisation included the evaluation of the degradation of the coatings, antibacterial, anti-thrombogenicity, radiopacity, and mechanical properties. The results showed that the metallic coatings inhibited bacterial growth, tho

SUBMITTER: Sousa AM 

PROVIDER: S-EPMC11683264 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature