Estimation of genetic admixture proportions via haplotypes.

ABSTRACT: Estimation of ancestral admixture is essential for creating personal genealogies, studying human history, and conducting genome-wide association studies (GWAS). The following three primary methods exist for estimating admixture coefficients. The frequentist approach directly maximizes the binomial loglikelihood. The Bayesian approach adds a reasonable prior and samples the posterior distribution. Finally, the nonparametric approach decomposes the genotype matrix algebraically. Each approach scales successfully to datasets with a million individuals and a million single nucleotide polymorphisms (SNPs). Despite their variety, all current approaches assume independence between SNPs. To achieve independence requires performing LD (linkage disequilibrium) filtering before analysis. Unfortunatel

SUBMITTER: Ko S 

PROVIDER: S-EPMC11683265 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature