Prognostic significance of perioperative circulating CD56^bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery.

ABSTRACT:

Introduction

Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. However, its role in prognosis of CRC remains unclear. Prior research has shown that surgical stress can suppress NKA. This study explores the relationship between NK cell/NKA and clinicopathological factors during the perioperative period in patients with CRC.

Methods

We prospectively enrolled 45 patients with CRC. Venous blood samples were collected preoperatively and on postoperative day 3 (POD3) and 30 (POD30). NKA was assessed by measuring the plasma levels of NK cell-secreted IFN-γ.

Results

NKA was significantly reduced on POD3 compared with baseline levels before surgery but

SUBMITTER: You JF 

PROVIDER: S-EPMC11683267 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature