Hypoxia-inducible factor prolyl hydroxylase inhibitor-induced thrombosis leading to transcatheter aortic valve dysfunction: a case report.

ABSTRACT:

Background

Transcatheter aortic valve replacement (TAVR) is a well-established treatment option for patients with severe aortic valve stenosis; however, clinical valve thrombosis is a major challenge.

Case summary

A 92-year-old woman underwent TAVR for severe aortic stenosis. One month later, the patient developed acute heart failure. As the progression of anaemia due to renal anaemia seemed to cause acute heart failure exacerbation, we started an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. After 2 weeks, the patient redeveloped shortness of breath. Transthoracic echocardiography revealed that the mean aortic valve pressure gradient (ΔP) increased from 9 to 54 mmHg, and the aortic valve area decreased from 1.93 to 0.86 cm². Blood wo

SUBMITTER: Ikuta A 

PROVIDER: S-EPMC11683361 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature